Original scientific paper
THE IMPACT OF SECONDARY HYPERPARATHYROIDISM ON ECHOCARDIOGRAPHIC PARAMETERS IN HEMODIALYSIS PATIENTS
EMIR MUZUROVIĆ
; Clinical Center of Montenegro, Internal clinic, Department of Endocrinology, Podgorica, Montenegro
SNEŽANA VUJOŠEVIĆ
; Clinical Center of Montenegro, Internal clinic, Department of Endocrinology, Podgorica, Montenegro
MARINA RATKOVIĆ
; Clinic of Urology and Nephrology, Department of Nephrology , Podgorica, Montenegro
DANILO RADUNOVIĆ
; Clinic of Urology and Nephrology, Department of Nephrology , Podgorica, Montenegro
DRAGICA BOŽOVIĆ
; Clinical center of Montenegro, Center for Laboratory Diagnostics, Podgorica, Montenegro
Abstract
Cardiovascular diseases are the leading cause of mortality in hemodialysis patients. Patients are exposed to a number of risk factors for cardiovascular complications, which are the result of uremia and dialysis. Aim of our study was to examine the incidence of secondary hyperparathyroidism and left ventricular hypertrophy, the interplay between them as predictors of mortality. This prospective study included 53 patients. All patients had measured echocardiographic parameters of left ventricular hypertrophy and laboratory parameters of bone metabolism. We followed the death rate of patients over two years. Elevated levels of PTH in the serum was present in 79.24% of patients, hypertrophy of the left chamber was recorded in 81.13% of patients. The survivors had lower values of PTH and phosphate levels which were significantly lower (p<0.05) in relation to deceased patients. Patients with poor outcome had higher LV mass index, lower EF and FSLV, larger diameters of interventricular septum and posterior wall (P <0.05). Left ventricular hypertrophy is premature cardiovascular disorder that develops rapidly during the progression of CKD and is based of uremic cardiomyopathy. Left ventricular hypertrophy is a strong indicator of mortality in patients with ESRD.
Keywords
PTH; echocardiographic parameters; cardiovascular disease; hemodialysis
Hrčak ID:
180120
URI
Publication date:
6.4.2017.
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