Original scientific paper
Plasma Cholinesterase Activity in Patients with Uterine Cervical Cancer during Radiotherapy
V. Bradamante
E. Šmigovec
D. Buković
J. Geber
D. Matanić
Abstract
The objectives of this study were to investigate: 1) the activity of pseudocholinesterase
(PChE) in patients with uterine cervical cancer in different stages (uterine cervical carcinoma
in stages II b and III and recurrent cervical carcinoma in stages III and IV a,b)
and to compare it to the enzyme activity in patients with benign tumour of the uterus,
and 2) the effects of radiotherapy on enzyme activity in those patients with uterine cervical
carcinoma for which the chosen treatment was radical radiotherapy. Thirty patients
with uterine cervical carcinoma in stages II b and III (Group A), sixteen patients with
recurrent cervical carcinoma in stages III and IV a,b (Group B) and thirty-eight patients
with benign tumours of the uterus (control, Group C) were evaluated and their
PChE activity was determined prior to any treatment (pre-therapy enzyme activity). All
eighty-four patients were free of any liver disease. The results have shown that the patients
of Group A had the pre-therapy PChE activity practically identical to those in
group C, but patients of Group B had significantly lower values of PChE with respect to
enzyme activities of Groups A and C (p< 0.001).That is to say, PChE activity was influenced
by the extent to which the malignancy had spread. Radical radiotherapy (up to 8
weeks in doses higher than 50 Gy into point A; average 80 Gy) which was the chosen
treatment only for patients from group A did not cause a significant inhibition of PChE
activity in any patients in comparison with their control values. With regard to the role
of PChE in hydrolysis of succinylcholine, our results about the influence of the malignant
disease and the radiotherapy on PChE activity are clinically significant.
Keywords
Hrčak ID:
17207
URI
Publication date:
16.12.2000.
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