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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 70 No. Suplement 2, 2016.

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BK VIRUS NEPHROPATHY IN A HEART TRANSPLANT RECIPIENT: THE FIRST DOCUMENTED CASE IN CROATIA

BRUNA BRUNETTA GAVRANIĆ ; Zagreb University Hospital Center, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
NIKOLINA BAŠIĆ-JUKIĆ ; Zagreb University Hospital Center, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
MARIJANA ĆORIĆ ; Zagreb University Hospital Center, Department of Pathology and Cytology, Zagreb, Croatia
BOŠKO SKORIĆ ; Zagreb University Hospital Center, Department of Cardiovascular Diseases, Zagreb, Croatia
DAVOR MILIČIĆ ; Zagreb University Hospital Center, Department of Cardiovascular Diseases, Zagreb, Croatia
PETAR KES ; Zagreb University Hospital Center, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia

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Abstract

As outcomes following heart transplantation have improved significantly over the last years, chronic kidney disease has become an increasingly prevalent complication in this population. Polyomavirus-associated nephropathy (PVAN) of native kidneys has also been recognized increasingly as a cause of kidney failure. We report the first case of PVAN occurring in the native kidneys of a solid-organ transplant recipient in Croatia as the eighth case described in the literature worldwide. A 65-year-old female with dilatative cardiomyopathy and good kidney function had a heart transplanted in 2012. Initial immunosuppressive therapy consisted of antithymocyte immunoglobulin with cyclosporine, mycophenolate mofetil and corticosteroids. Soon after transplantation, her kidney function began to fail progressively. Biopsy of the native kidneys revealed PVAN, and everolimus was introduced in immunosuppressive therapy. Nevertheless, her renal dysfunction progressed and she is now being evaluated for cadaveric kidney transplantation. PVAN should be considered in the differential diagnosis of new-onset renal failure following non-kidney solid organ transplantation. Early diagnosis is essential for prevention of irreversible renal damage.

Keywords

polyomavirus-associated nephropathy; heart transplantation; kidney failure

Hrčak ID:

180158

URI

https://hrcak.srce.hr/180158

Publication date:

6.4.2017.

Article data in other languages: croatian

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