Periodicum biologorum, Vol. 119 No. 1, 2017.
Original scientific paper
https://doi.org/10.18054/pb.v119i1.4180
Comparative effectiveness of diet alone and diet plus metformin treatment on omentin levels in type 2 diabetes patients with nonalcoholic fatty liver disease: a prospective randomized trial
Ibrahim Arslan
Turgay Ulas
Emel Yigit Karakas
Mehmet Demir
Mehmet Ali Eren
Aysenur Torun
Tevfik Sabuncu
Abstract
Aim: The aim of this study was to compare the effectiveness of diet alone and diet plus metformin treatment on omentin levels in type 2 diabetes patients with nonalcoholic fatty liver disease.
Methods: Consecutively 88 patients who had hepatic steatosis with type-2 DM were recruited for the study. For randomization, 28 patients who had exclusion criteria were excluded from the study. The remaining patients (n = 60) were randomized into two groups. Only diet therapy were given to Group 1(n = 30) and metformin 2 gram/day plus diet were given to group 2 (n = 30) during 3 months. During the follow-up period 5 patients in group 1 and 1 patient in group 2 did not come for follow-up. Therefore we evaluated 25 patients in group 1 and 29 patients in group 2. Omentin levels were analyzed at admission and at the end of the study.
Results: There was a statistically significant difference in the values of body weight, body mass index, waist and hip circumference, body fat percentage (%), and omentin in group 1; and in the values of body weight, BMI, waist and hip circumference, body fat percentage (%), and omentin in group 2. Omentin levels were significantly decreased with the treatment in both groups (5.37 ± 1.31 ng/ml to 4.00 ± 1.46 ng/ml in group 1; 6.96 ± 2.10 ng/ml to 3.92 ± 0.89 ng/ml in group 2, p = 0.001 respectively). When compared the percentage of changes between two groups, it was found that the omentin value was more decreased in group 2 (p = 0.032).
Conclusions: Although diet and diet plus metformin treatment decreased the omentin levels, diet plus metformin treatment would be more beneficial in type 2 diabetes patients with nonalcoholic fatty liver disease.
Keywords
Nonalcoholic fatty liver disease; omentin; type 2 diabetes mellitus
Hrčak ID:
180334
URI
Publication date:
30.3.2017.
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