Skip to the main content

Archives of Industrial Hygiene and Toxicology, Vol. 15 No. 3, 1964.

Original scientific paper

Protective effects of some cholinolytics in armine poisoning

B. Bošković ; Farmakološki institut Medicinskog fakulteta, Sarajevo
D. Potkonjak ; Farmakološki institut Medicinskog fakulteta, Sarajevo
P. Stern ; Farmakološki institut Medicinskog fakulteta, Sarajevo

Full text: bosnian pdf 7.272 Kb

page 263-268

downloads: 314

cite

Abstract

Nine cholinolytics and one choline aoetylase inhiihitor (Morin) have been examined as potential protecting agents against armine poisoning. Only Hydroxyzine, Disipal and Ponalid were found to protect mice against one LD50 of armine. In combination with pyridine 2-aldoxime methchloride (PAM-2-Cl) the best effect was found with Aturban, which protected 50 per cent of mice against 4 mg/kg of armine (X LD50). The quaternary cholinolytics Antrenyl and atropine, combined with PAM-2-Cl, protected about 50 per cent of animals against 4 X LD50 of armine, similarly to a combination of central cholinolytics. Tropenzylium and Hydroxyzine. Other cholinolytics showed weaker protective properties.

Keywords

Hrčak ID:

180443

URI

https://hrcak.srce.hr/180443

Publication date:

21.9.1964.

Article data in other languages: bosnian

Visits: 857 *