Short communication, Note

Distribution of ApoE Variants in Four Northeast Indian Populations

Albeliz Santiago-Colón ; Division of Epidemiology, Department of Environmental Health, University of Cincinnati, OH
Rebekah Karns ; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center
Sarabjit Mastana ; Human Genomics Laboratory, School of Sport, Exercise and Health Sciences, Loughborough University, UK
Ranjan Deka ; Division of Epidemiology, Department of Environmental Health, University of Cincinnati, USA

Abstract

Polymorphisms in the human apolipoprotein E gene (ApoE) have been extensively studied for associations with various complex diseases. Numerous population genetic studies have reported the distribution of ApoE alleles in global populations. In this study, we present new data on the distribution of ApoE polymorphisms among four Northeast Indian populations, namely, Kachari, Rabha, Ahom, and an Indo-European caste group. Allele frequencies, Hardy-Weinberg equilibrium, genotype and phenotype probabilities were based on the two SNPs, rs7412 and rs429358. Of the APOE genotypes, derived from rs429358 and rs7412 SNPs, 3/3 and 3/4 genotypes were the most frequent in all groups and only Rabha showed higher frequency of 2/3 genotype. The Kachari population showed the highest frequency of CT genotype for SNP rs429358 and the highest frequency of allele *E4 in the Indian subcontinent, which was much higher than other study populations of eastern India.

Keywords

apolipoproteins E; apolipoprotein E2; apolipoprotein E3; apolipoprotein E4; Single Nucleotide Polymorphism; Northeast India; population genetics

Hrčak ID:

180632

URI

https://hrcak.srce.hr/180632

Publication date:

27.12.2016.

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