Original scientific paper

Study of dermal toxicity of organophosphorus compounds. I. Parathion toxicity in relation to the skin surface and the technique of application

M. Vandekar ; Institut za medicinska istraživanja i medicinu rada, Zagreb
I. Komanov ; Institut za medicinska istraživanja i medicinu rada, Zagreb

Abstract

The effect of the preparation of the rat's skin surface and the covering of the contaminated area on dermal Parathion toxicity was investigated. The removal of the fatty layer from the clipped back skin area 24 hours prior to the application of the poison had no effect on Parathion toxicity. Parathion toxicity was reduced to about twice when the contaminated area was covered with a polythene sheet, and to about three and a half times when cevered with a leukoplast. The experiments, in which the possibility of ingestion of the poison in uncovered rats was partly or completely avoided, have shown that higher LD50 values obtained by covering the contaminated area were not due to the prevented introduction of the poison by ingestion but to a reduced penetration of Parathion through the skin. This may be explained by the adhesion of the poison to the polythene sheet or leukoplast by which the contaminated area was covered.

Keywords

Hrčak ID:

181419

URI

https://hrcak.srce.hr/181419

Publication date:

13.3.1963.

Article data in other languages: croatian

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