Original scientific paper

The influence of chelating agents on uranium retention in the kidney

Krista Kostial ; Institut za medicinska istraživanja i medicinu rada, Zagreb
Kata Voloder ; Institut za medicinska istraživanja i medicinu rada, Zagreb
V.B. Vouk ; Institut za medicinska istraživanja i medicinu rada, Zagreb
O. Weber ; Institut za medicinska istraživanja i medicinu rada, Zagreb

Abstract

In rats treated with uranyl nitrate (7,6 mg per kilogramme of body weight) 28 per cent of the applied dose was found in the kidney three hours after the intraperitoneal injection. In animals receiving diethylenetriamine penta-acetic acid (DTP A) by intraperitoneal injection (1 mM per kilogramme of body weight) immediately after the treatment with uranyl nitrate a significant reduction of the uranium content of the kidneys was observed. Only 12 per cent of the injected dose was found in the kidneys. The application of hydroxydiphenylether phosphate (HDPP), however, caused the opposite effect, resulting in a 55 per cent retention of uranium by the kidney. The possible mechanism of this action is discussed

Keywords

Hrčak ID:

181664

URI

https://hrcak.srce.hr/181664

Publication date:

14.12.1962.

Article data in other languages: croatian

Visits: 735 *