Original scientific paper

Effect of DFP on the resorption from subcutaneous tissue

B. Bošković ; Institut za farmakologiju Medicinskog fakulteta u Sarajevu
D. Leković ; Institut za farmakologiju Medicinskog fakulteta u Sarajevu
P. Stern ; Institut za farmakologiju Medicinskog fakulteta u Sarajevu

Abstract

In diisopropyl fluorophosphate rat poisoning the resorption of sulfacetamide from subcutaneous tissue into the blood is delayed owing to the oedema of subcutaneous tissue. The administration of atropine does not normalize the resorption of sulfacetamide in DFP poisoning. If cholinesterase inhibited by DFP is reactivated with TMB-4 or P AM-2, there is no longer any difference in resorption between poisoned and control animals. Out of the two oximes studies - TMB-4 and P AM-2 - only TMB-4 decreases the resorption of sulfacetamide from subcutaneous tissue into the blood, while PAM-2 has no effect on this resorption.

Keywords

Hrčak ID:

181937

URI

https://hrcak.srce.hr/181937

Publication date:

14.3.1962.

Article data in other languages: croatian

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