Original scientific paper
The therapeutic effect of PAM-2 Cl on armin poisoned mice
Z. Binenfeld
; Institut za toksikologiju VMA, Beograd
V. Vojvodić
; Institut za toksikologiju VMA, Beograd
V. Božić
; Institut za toksikologiju VMA, Beograd
Abstract
PAM-2 Cl (pyridine-2-aldoxime methyl chloride) was obtained by allowing the solution of PAM-2 (pyridine-2-aldoxime methyl iodide) to pass through the anion exchanger Duolit A-30 or by boiling a saturated PAM-2 solution with AgCI. The yield was 35-50%, m. p. 218-220° C (uncor.), solubility in water 1:1. The concentration of 1.10-4 PAM-2 Cl produces a 25% inhibition of the rabbit's plasma and erythrocyte ChE. The concentration of 1.10-4 PAM-2 Cl produces, in an hour, 80% reactivation of the same enzymes inhibited by armin (ethyl-p-nitrophenyl ethylphosphonate). The same results were obtained with PAM-2. The protective effect of P AM-2 Cl on the mice poisoned by armin is equal to that of PAM-2 regarding both the dose and the time of application.
Keywords
Hrčak ID:
182162
URI
Publication date:
23.11.1961.
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