Croatica Chemica Acta, Vol. 90 No. 1, 2017.
Original scientific paper
https://doi.org/10.5562/cca3013
A Highly Efficient and Green Catalytic Synthesis of 3,4-dihydro-pyrimidin-2-(1H)-ones (Thiones) Using 3-sulfonic Acid-1-imidazolopyridinium Hydrogen Sulfate under Solvent-free Conditions
Mohammad Bakherad
; School of Chemistry, Shahrood University of Technology, Shahrood, 3619995161, Iran
Mohaddeseh Javanmardi
; School of Chemistry, Shahrood University of Technology, Shahrood, 3619995161, Iran
Raheleh Doosti
; School of Chemistry, Shahrood University of Technology, Shahrood, 3619995161, Iran
Reza Tayebee
; Department of Chemistry, Hakim Sabzevari University, Sabzevar, 9617976487, Iran
Abstract
The ionic liquid catalyst 3-sulfonic acid-1-imidazolopyridinium hydrogen sulfate, [Simp]HSO4 was found to be a highly active and green catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) under the solvent-free conditions. Avoiding organic solvents during the chemical reactions leading to an economic approach is effective. The reactions are characterized by high efficiency, short reaction time, high product yield, simple experimental procedure, availability of catalyst, and environmentally-friendly reaction conditions.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
Biginelli reaction; [Simp]HSO4 catalyst; 3,4-dihydropyrimidin-2(1H)-ones (thiones); solvent-free
Hrčak ID:
182671
URI
Publication date:
2.1.2017.
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