Reumatizam, Vol. 62 No. suppl. 1, 2015.
Review article
THE ROLE OF BIOMARKERS IN OSTEOARTHRITIS
Mislav Radić
Dušanka Martinović Kaliterna
Abstract
In the next few decades we will witness an aging population
with an increase in degenerative musculoskeletal
conditions affecting the costs to society. The majority of
conditions such as osteoarthritis are primarily diagnosed
radiographically, by which time the disease process has
often advanced and is difficult to treat. The commonly
available studies provide inadequate information as to the
exact pain generator, and findings often do not correlate
with the patients’ symptoms or functional capacity. Personalized
medicine is an emerging field that involves formulating
treatments based on a patient’s own biology. The importance of developing biological markers (biomarkers)
is evident. In osteoarthritis, biomarkers could provide an
early non-invasive method of assessing the location and
severity of tissue damage and the presence of inflammation.
With the help of biomarkers treatment targets could be
identified and treatments created according to specific subgroups,
stages, and individual needs of each patient. The
present article is a review of the development of biomarker
candidates in osteoarthritis.
Keywords
osteoarthritis; biomarkers; diagnosis; prognosis
Hrčak ID:
182726
URI
Publication date:
10.10.2015.
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