Review article

RHEUMATIC DISEASES AND MALIGNANSY – WHERE IS THE ASSOCIATION?

Višnj Prus
Jasminka Milas-Ahić
Željka Kardum
Ivana Kovačević

Abstract

Patients with inflammatory autoimmune rheumatic diseases,
especially those with rheumatoid arthritis, systemic lupus
erythematosus, Sjögren’s syndrome, dermatomyositis,
and systemic sclerosis, are at increased risk of malignancies,
including leukemia and lymphoproliferative syndromes.
An increased incidence of malignant disease is associated
with autoimmunity, chronic inflammatory activity,
as well as immunomodulatory and immunosuppressive therapy. Rheumatic manifestations can be part of paraneoplastic
syndrome, which may further affect the differential
diagnosis, disease monitoring, or treatment strategies
along with the assessment of individual risks and the impact
of environmental factors.

Keywords

rheumatic disease; malignacy; comorbidity; paraneoplastic syndrome; treatment

Hrčak ID:

182779

URI

https://hrcak.srce.hr/182779

Publication date:

10.10.2015.

Article data in other languages: croatian

Visits: 3.028 *