Review article

SJÖGREN’S SYNDROME AND LYMPHOPROLIFERATIVE DISEASES

Joško Mitrović
Jadranka Morović Vergles

Abstract

Sjögren’s syndrome (SS) is a chronic systemic autoimmune
disease characterized by a lymphocytic infiltration and
progressive destruction of exocrine glands, in particular
the lacrimal and salivary glands, leading to ocular and oral
dryness. Patients with SS have a higer risk for development
of lymphoproliferative disorders. Non-Hodgkin’s lymphoma
(NHL) is the most serious complication and carries a
high risk of mortality in patients with SS. The evolution
from benign lymphocytic infiltration to malignant NHL
is a multi-step process. The chronic inflammation and excessive stimulation of B cells, cytokine activation, and
oncogenic events with the presence of predictive risks factors
may lead to the development of lymphoma. The most
frequent type of NHL is marginal zone lymphoma of the
mucosa-associated lymphoid tissue (MALT), affecting the
salivary glands in the majority of cases.

Keywords

Sjögren’s syndrome; salivary glands; lymphoproliferative disorders; lymphoma; non-Hodgkin

Hrčak ID:

182783

URI

https://hrcak.srce.hr/182783

Publication date:

10.10.2015.

Article data in other languages: croatian

Visits: 5.877 *