Review article

SYSTEMIC SCLEROSIS AND MALIGNANT DISEASES

Dijana Perković
Dušanka Martinović Kaliterna

Abstract

Patients with systemic sclerosis (SSc) are at increased risk
of malignancies in comparison with the general population.
The most common is lung cancer, followed by hematologic
diseases, malignant tumors of the gastrointestinal
tract, breast, and non-melanoma skin cancers. Duration of
the disease, older age at the moment of diagnosis, smoking,
and alcohol consumption significantly increase the risk of
malignancy. SSc, scleroderma-like syndrome, and Raynaud phenomenon can develop within paraneoplastic syndrome.
The association of SSc and malignancies could be explained
by a unique genetic susceptibility for the development of
malignancies or autoimmune diseases, or the exposure to
certain environmental factors or autoantibodies.

Keywords

systemic sclerosis; malignoma; scleroderma-like syndrome

Hrčak ID:

182791

URI

https://hrcak.srce.hr/182791

Publication date:

10.10.2015.

Article data in other languages: croatian

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