Original scientific paper
The action of NN'-trimethylenebis(4 - hydroxyiminomethylpyridiniumbromide) (TMB - 4) on acute lethal anticholinesterase poisoning in mice
M. Milošević
; Institute of Pharmacology, Medical Faculty, Belgrade
V. Vojvodić
; Institute of Pharmacology, Medical Faculty, Belgrade
V. Milošević
; Institute of Pharmacology, Medical Faculty, Belgrade
Abstract
Poziomek, Hackley and Steinberg (1958) and, independently, Hobbiger, O'Sullivan and Sadler (1958) have recently described a series of NN'-polymethylenebis(4-hydroxyiminomethyl-pyridinium) compounds, which are potent reactivators of cholinesterases inhibited by organophosphate antichobinesterases. The most effective compound in this series NN'-trimethylenebis( 4-hydroxyimino-methyl-pyridinium bromide) (TMB-4) was reported to be an effective agent in protecting animals from the lethal poisoning by methylphosphorofluoridate (SARIN), DFP and TEPP (Bay, Krop and Yates, 1958; Berry, Davies and Green, 1959; Hobbig er and Sadler, 1959). In this paper additional experiments are described, carried out to estimate the antagonism of TMB-4 toward some other organo-P-compounds. A number of specific nonphosphorus anticholinesterases are included as well.
Keywords
Hrčak ID:
182985
URI
Publication date:
14.9.1959.
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