Original scientific paper
Efect of electrophoretic fractions of Vip. ammodytes venom on coagulation in vitro
G.A. Šestakov
; Institut za patološku fiziologiju, Medicinski fakultet, Skopje
I.I. Dejanov
; Institut za patološku fiziologiju, Medicinski fakultet, Skopje
I.S. Tadžer
Abstract
Coagulation studies on saline eluates of bands cut from a paper strip on which vipera ammodytes venom was electrophoresed at low temperature (2° C) show coagulant and anticoagulant principles. The coagulant substance migrates toward the anode, the anticoagulant fraction migrates on the opposite site towards the cathode. The clot-promoting eluate of the venom depends in his activity on the concentration of prothrombin, proaccelerin and the factor VII complex. An obvious enhancement in the activity of the coagulant substance could be demonstrated in the presence of platelets and platelets substituent cephalin. The anticoagulant fraction show antithromboplastin-like activity, which was inactivated by platelets and the Christmas-factor.
Keywords
Hrčak ID:
183076
URI
Publication date:
23.6.1959.
Visits: 811 *