Acta clinica Croatica, Vol. 56. No. 1., 2017.
Original scientific paper
https://doi.org/10.20471/acc.2017.56.01.02
Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?
Davor Sporiš
; Osijek School of Medicine, Josip Juraj Strossmayer University, Osijek; Dubrava University Hospital, Department of Neurology
Silvio Bašić
; Osijek School of Medicine, Josip Juraj Strossmayer University, Osijek; Dubrava University Hospital, Department of Neurology
Jadranka Sertić
; Zagreb University Hospital Center, Clinical Institute of Laboratory Diagnosis
Darija Mahović Lakušić
; Department of Neurology, Zagreb, Croatia
Tomislav Babić
; Worldwide Clinical Trials, London, UK
Abstract
The aim of the study was to evaluate the possible association between Apo E polymorphisms and age at seizure onset in patients with non-lesional temporal lobe epilepsy. Eighty patients with non-lesional temporal lobe epilepsy with or without bilateral tonic-clonic propagation were analyzed. Age at seizure onset was defined as age at the first unequivocal seizure (excluding febrile convulsions). ApoE alleles were determined by a procedure where genome DNA was amplified by chain reaction along with polymerase, using the LightCycler kit (Roche) for ApoE mutations on codons 112 and 158. There was a statistically significant difference between the groups of patients with ApoE ε2/3 and ε3/4 genotypes (p=0.03), but not between patients with ApoE ε2/3 and ε3/3, and those with ApoE ε3/4 and ε3/3. In conclusion, the results of our study suggested positive association of a specific ApoE genotype and onset of non-lesional temporal lobe epilepsy.
Keywords
Apolipoprotein E2; Polymorphism, genetic; Epilepsy, temporal lobe; Age at onset
Hrčak ID:
184168
URI
Publication date:
1.3.2017.
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