Acta clinica Croatica, Vol. 56. No. 1., 2017.
Original scientific paper
https://doi.org/10.20471/acc.2017.56.01.11
High Tumor Stroma Proportion is a Worse Prognostic Factor in Colorectal Cancer
Josipa Flam
; Department of Oncology, Osijek University Hospital Center; School of Medicine
Damir Gugić
; Department of Oncology, Osijek University Hospital Center; School of Medicine
Mirta Benšić
; Department of Mathematics, Josip Juraj Strossmayer University, Osijek
Snježana Tomić
; Clinical Department of Pathology, Split University Hospital Center, Split
Jasmina Rajc
; School of Medicine; Clinical Department of Pathology, Osijek University Hospital Center, Osijek, Croatia
Abstract
High stroma proportion appears to be a very important prognostic factor in esophageal and breast cancer. Previous researches have shown that it might have a similar effect on colorectal cancer. The aim of this study was to determine whether tumor stroma proportion influenced patient survival. This retrospective study included 236 patients with colorectal cancer having undergone surgery in 2006 and 2007 at Osijek University Hospital Center. Location with the highest stroma proportion at the site of deepest tumor invasion was determined. Patients were divided into the groups with high stroma proportion (>50%) and low stroma proportion (≤50%). Stroma proportion showed a statistically significant correlation with tumor stage. Kaplan-Meier survival curves yielded a statistically significant difference in patient overall survival (Cox ph model p=0.016) and progressionfree survival (Cox ph model, p=0.0188) according to stroma proportion. Study results showed a statistically significantly shorter overall survival and progression-free survival in patients with high stroma proportion.
Keywords
Colorectal neoplasms; Stromal cells; Survival; Disease-free survival; Disease progression; Prognosis
Hrčak ID:
184326
URI
Publication date:
1.3.2017.
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