Psychiatria Danubina, Vol. 29 No. 2, 2017.
Original scientific paper
https://doi.org/10.24869/psyd.2017.195
HUMAN NEUROPSIN GENE IN DEPRESSION
Kinga Bobińska
; Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Joanna Mossakowska-Wójcik
; Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Janusz Szemraj
; Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland
Piotr Gałecki
; Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Marlena Zajączkowska
; Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Monika Talarowska
; Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Abstract
Background: Neuropsin (NP, kallikrein 8, KLK8) - a kallikrein gene-related (KLK) endoprotease - plays a key role in neuroplasticity
processes, since intracellular signal cascades and regulation of gene expression are engaged in long-term synaptic plasticity.
The main aim of this paper is to compare expression of the human neuropsin gene on the mRNA level in a group of patients
diagnosed with depression and in a group of healthy subjects who have never been treated psychiatrically.
Subjects and methods: 291 people, aged 18-67, were qualified to participate in the experiment: major recurrent depression
group (MRD) and the control group (CG). Designations were carried out for the human NP gene (hNP).
Results: For hNP gene expression at the mRNA level was higher in patients with depression than in the CG (p<0.005). A
Spearman's rank correlation analysis did not reveal any statistically significant relationship between the intensity of the disease
measured using the HDRS scale and expression on the mRNA level for the hNP gene. Expression for the hNP gene in the entire
group analysed increased with age of the examined individuals (p<0.005).
Conclusion: Expression of the hNP gene on the mRNA level, evaluated based on peripheral blood, is significantly higher in the
patients with MRD than in the healthy subjects.
Keywords
major recurrent depression; human neuropsin; kallikrein
Hrčak ID:
184774
URI
Publication date:
28.6.2017.
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