Review article

Adverse Drug Reactions Associated with Statin Therapy

Luka Bielen ; Zavod za intenzivnu medicinu KBC Zagreb i Medicinski fakultet Sveučilišta u Zagrebu

Abstract

Statins are the most commonly used drugs for the treatment of hypercholesterolemia, with the aim of primary and secondary prevention of cardiovascular morbidity and mortality. Statins are considered safe drugs with lower incidence of adverse reactions than other hypolipemics. Skeletal muscle and liver related toxicities need to be mentioned as possible adverse reactions. In contrast to earlier recommendations, it is not considered necessary to conduct routine monitoring of transaminase levels during treatment with statins. New guidelines indicate that it does not lead to early recognition of clinically important liver toxicity due to statin treatment and is most often associated with drug interactions. Pharmacokinetic interactions of statins are important for the development of myopathy and rhabdomyolysis. Therefore, an individualized treatment approach is recommended considering the different metabolic pathways of various representatives of hypolipemic drugs.

Keywords

statins; adverse drug reactions; rhabdomyolysis; liver toxicity

Hrčak ID:

185269

URI

https://hrcak.srce.hr/185269

Publication date:

26.7.2017.

Article data in other languages: croatian

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