Cardiologia Croatica, Vol. 12 No. 7-8, 2017.
Professional paper
https://doi.org/10.15836/ccar2017.331
Metabolic Syndrome – Myth or Reality in the Endocrinology Clinic.
Mirsala Solak
; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Abstract
Metabolic syndrome is a common clinical problem that encompasses interconnected conditions: hypertension, dyslipidemia, hyperglycemia, and central obesity. It is important because these patients have significantly increased cardiovascular risk and risk of developing Type 2 diabetes. These metabolic disorders more commonly manifest as a syndrome, and together they significantly increase risk in comparison with a single isolated metabolic disorder. Obesity and insulin resistance seem to play a major role in the pathogenesis of metabolic syndrome. Chronic proinflammatory state, endothelial dysfunction, and procoagulant condition contribute as well. Lifestyle modification is the initial intervention of choice, thereby improving all metabolic disorders that are part of this syndrome. Pharmacological treatment should be considered in order to reduce specific risk factors for cardiovascular disease when lifestyle measures fail. The ultimate goal of treatment is the reduction of the systemic effects of metabolic syndrome.
Keywords
metabolic syndrome; insulin resistance; cardiovascular risk; diabetes mellitus; adiposity
Hrčak ID:
185348
URI
Publication date:
21.7.2017.
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