Original scientific paper
The production of gastric ulceration in rabbits by perivagal injections of tetanus toxin
N. Ambache
; Departement of Physiology, University College, London
O.C.J. Lippold
; Departement of Physiology, University College, London
Abstract
Gastric erosions have been produced in rabbits by subperitoneal injections of tetanus toxin along the vagus nerves in relation to the oesophagus or anterior wall of the stomach, and into the central end of the cut cervical vagus on one side. Ten rabbits injected in this way with 0.3-1 mg of toxin all showed acute erosions, often haemorrhagic, after periods of 12-146 hr. (a) Four control rabbits treated identically with boiled toxin did not exhibit ulceration. (b) Of 19 normal rabbit stomachs, examined at random, only one had a small erosion. (c) The intravenous injection of toxin was without ulcerative effect. In 9 rabbits the vagi were both cut subdiaphragmatically. Four were killed either 6 or 42 days later, and had no erosion. The other 5 were killed (or died) at comparable times but had been injected in the usual way with toxin 28-48 hr. before death; all showed erosions.
Keywords
Hrčak ID:
186378
URI
Publication date:
14.3.1955.
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