Original scientific paper
Epidemiology of pemphigus in Turkey: One-year prospective study of 220 cases
Savas Yayli
; Dept of DermatologyKaradeniz Technical University
Mehmet Harman
Emel Bulbul Baskan
Ayse Akman Karakas
Yeser Genc
Bengu Gerceker Turk
Evren Odyakmaz Demirsoy
Suhan Gunasti
Serap Gunes Bilgili
Nilsel Ilter
Ayten Ferahbas
Ekin Savk
Fatma Sule Afsar
Sema Aytekin
Tamer Irfan Kaya
Sibel Berksoy Hayta
Züleyha Ozgen
Mehmet Salih Gurel
Ercan Caliskan
Didem Didar Balci
Sule Gungor
Yelda Kapicioglu
Pinar Ozuguz
Sebnem Aktan
Asena Dogramaci
Ibrahim Kokcam
Nahide Onsun
Deniz Seckin
Murat Durdu
Recep Dursun
Munise Daye
Nursel Dilek
Ercan Karabacak
Asli Bilgic Temel
Cengizhan Erdem
Ece Altun
Dilek Gungor
Demet Kartal
Melih Akyol
Esra Koku Aksu
Soner Uzun
Abstract
Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n=192; 87.3%), followed by pemphigus foliaceus (n=21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n=83; 43.2%). The mean Pemphigus Disease Area Index was 28.14±22.21 (mean ± Standard Deviation). The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.
Keywords
Hrčak ID:
187812
URI
Publication date:
19.10.2017.
Visits: 1.881 *