Reumatizam, Vol. 64 No. suppl. 1, 2017.
Review article
PATHOGENESIS OF PSORIATIC ARTHRITIS
Srđan Novak
Tatjana Zekić
Abstract
Th e occurrence of psoriatic arthritis is associated with genetic, immune, and environmental factors. Psoriasis and
psoriatic arthritis are associated with MHC class I gene alleles; psoriasis with HLA-C*06, and psoriatic arthritis with
HLA-B*08, B*27, B*38, and B*39. Both innate and adaptive immunity contribute to the pathogenesis of psoriatic
arthritis. Key cytokines in the pathogenesis of psoriatic arthritis are IL 12/23, IL 17A, and TNFα, which is why current
treatment aims at blocking them. Bone erosions are mediated by NF-κB, IL-17, and RANKL signaling pathways. Recent
studies emphasize biomechanical stress on tendons and microtrauma as initial factors of infl ammation. Subclinical gut
infl ammation and microbial dysbiosis are possible triggers of disease, too. Recently acquired knowledge about key molecules
in the pathogenesis of psoriatic arthritis will lead to new investigations and treatment opportunities.
Keywords
Arthritis, psoriatic – genetics, immunology, metabolism; HLA antigens – genetics; Genetic predisposition to disease; Interleukin-17 – immunology, metabolism; Interleukin-23 – immunology, metabolism; T- lymphocytes – immunology
Hrčak ID:
188331
URI
Publication date:
25.10.2017.
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