Review article

ENTHESITIS AND DACTYLITIS – MANIFESTATIONS OF PSORIATIC ARTHRITIS

Jadranka Morović-Vergles
Ana Gudelj Gračanin

Abstract

Enthesitis and dactylitis are important manifestations of psoriatic arthritis (PsA) and have a negative impact on
function and quality of life of PsA patients. High biomechanical stress and cytokines (interleukin-23/Th 17 pathway)
are implicated in the pathogenesis of enthesitis and dactylitis. Enthesitis is an early lesion in PsA that may precede
synovitis. Diagnosis of enthesitis and dactylitis is based on clinical assessment. Power Doppler ultrasound is more
sensitive than physical exam for the detection of enthesitis. Drugs that target TNF, interleukin-17, interleukin-17R,
interleukin-12/23, and PDE4 are eff ective for enthesitis and dactylitis.

Keywords

Arthritis, psoriatic – diagnostic imaging, pathology, physiopathology; Enthesopathy – diagnostic imaging, physiopathology; Cytokines – metabolism; Finger joint – pathology; toes – pathology; Ultrasonography, doppler

Hrčak ID:

188333

URI

https://hrcak.srce.hr/188333

Publication date:

25.10.2017.

Article data in other languages: croatian

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