Review article
Overview of the Most Important Antipsychotics and their Mechanisms of Action
Maja Živković
Full text: english pdf 186 Kb
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cite
APA 6th Edition
Živković, M. (2017). Overview of the Most Important Antipsychotics and their Mechanisms of Action. Medicus, 26 (2 Psihijatrija danas), 133-0. Retrieved from https://hrcak.srce.hr/189038
MLA 8th Edition
Živković, Maja. "Overview of the Most Important Antipsychotics and their Mechanisms of Action." Medicus, vol. 26, no. 2 Psihijatrija danas, 2017, pp. 133-0. https://hrcak.srce.hr/189038. Accessed 19 Oct. 2024.
Chicago 17th Edition
Živković, Maja. "Overview of the Most Important Antipsychotics and their Mechanisms of Action." Medicus 26, no. 2 Psihijatrija danas (2017): 133-0. https://hrcak.srce.hr/189038
Harvard
Živković, M. (2017). 'Overview of the Most Important Antipsychotics and their Mechanisms of Action', Medicus, 26(2 Psihijatrija danas), pp. 133-0. Available at: https://hrcak.srce.hr/189038 (Accessed 19 October 2024)
Vancouver
Živković M. Overview of the Most Important Antipsychotics and their Mechanisms of Action. Medicus [Internet]. 2017 [cited 2024 October 19];26(2 Psihijatrija danas):133-0. Available from: https://hrcak.srce.hr/189038
IEEE
M. Živković, "Overview of the Most Important Antipsychotics and their Mechanisms of Action", Medicus, vol.26, no. 2 Psihijatrija danas, pp. 133-0, 2017. [Online]. Available: https://hrcak.srce.hr/189038. [Accessed: 19 October 2024]
Full text: croatian pdf 186 Kb
page 133-139
downloads: 782
cite
APA 6th Edition
Živković, M. (2017). Overview of the Most Important Antipsychotics and their Mechanisms of Action. Medicus, 26 (2 Psihijatrija danas), 133-0. Retrieved from https://hrcak.srce.hr/189038
MLA 8th Edition
Živković, Maja. "Overview of the Most Important Antipsychotics and their Mechanisms of Action." Medicus, vol. 26, no. 2 Psihijatrija danas, 2017, pp. 133-0. https://hrcak.srce.hr/189038. Accessed 19 Oct. 2024.
Chicago 17th Edition
Živković, Maja. "Overview of the Most Important Antipsychotics and their Mechanisms of Action." Medicus 26, no. 2 Psihijatrija danas (2017): 133-0. https://hrcak.srce.hr/189038
Harvard
Živković, M. (2017). 'Overview of the Most Important Antipsychotics and their Mechanisms of Action', Medicus, 26(2 Psihijatrija danas), pp. 133-0. Available at: https://hrcak.srce.hr/189038 (Accessed 19 October 2024)
Vancouver
Živković M. Overview of the Most Important Antipsychotics and their Mechanisms of Action. Medicus [Internet]. 2017 [cited 2024 October 19];26(2 Psihijatrija danas):133-0. Available from: https://hrcak.srce.hr/189038
IEEE
M. Živković, "Overview of the Most Important Antipsychotics and their Mechanisms of Action", Medicus, vol.26, no. 2 Psihijatrija danas, pp. 133-0, 2017. [Online]. Available: https://hrcak.srce.hr/189038. [Accessed: 19 October 2024]
Abstract
Although antipsychotics primarilly act by blocking dopamine D2 receptors, they also influence other neurotransmitter systems such as the serotonergic, the histaminergic, the adrenergic and the cholinergic system. Additionally, they have an indirect effect on the GABA and the glutaminergic system and ultimately on gene expression. Such a complex mechanism of action has been shown to be effective in the treatment of positive symptoms of schizophrenia. However, in the treatment of negative, affective and cognitive symptoms, the expected therapeutic effect has not yet been achieved. Therefore, further research and development of new drugs, either as an augmentation to existing antipsychotics, or completely new molecules with a wider spectrum and activity on psychopathological domain of shizophrenia, are necessary to improve the treatment. Within that context, this paper will discuss the mechanisms of action of antipsychotics responsible for the therapeutic effects and development of adverse effects, as well as pharmacologic properties of individual antipsychotics.
Keywords
antipsychotics; neurotransmitters; receptors; dopamine; serotonin
Hrčak ID:
189038
URI
https://hrcak.srce.hr/189038
Publication date:
8.11.2017.
Article data in other languages:
croatian
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