Review article

https://doi.org/10.2478/acph-2018-0004

Effective anti-adhesives of uropathogenic Escherichia coli

ROSANA RIBIĆ ; Research and Development Department, Tesla Ltd, 42 244 Klenovnik, Croatia
TOMISLAV MEŠTROVIĆ ; Clinical Microbiology and Parasitology Unit, Polyclinic “Dr. Zora Profozić”, 10000 Zagreb, Croatia
MARIJANA NEUBERG ; Department of Biomedical Sciences, University Centre Varaždin, University North, 42000 Varaždin, Croatia
GORAN KOZINA ; Department of Biomedical Sciences, University Centre Varaždin, University North, 42000 Varaždin, Croatia

Abstract

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection. Design of receptor analogues that competitively bind to UPEC surface adhesins placed at the top of pili organelles led to the development of anti-adhesive drugs that are increasingly recognized as important and promising alternatives to antibiotic treatment of UTIs.

Keywords

urinary tract infections; type I fimbriae; P pili; mannosides; cranberry; polyphenols

Hrčak ID:

189688

URI

https://hrcak.srce.hr/189688

Publication date:

31.3.2018.

Visits: 2.562 *