Original scientific paper

https://doi.org/10.24869/psyd.2017.431

ELEVATED SERUM C-REACTIVE PROTEIN LEVEL IS NOT ASSOCIATED WITH SERUM NITRIC OXIDE IN PATIENTS WITH POSTTRAUMATIC STRESS DISORDER

Almir Fajkić orcid.org/0000-0002-1985-9355 ; Department of Pathophysiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Miralem Musić ; Department of Pathophysiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Alma Džubur Kulenović orcid.org/0000-0002-1883-7111 ; Psychiatric Clinic, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina
Asija Začiragić ; Department of Human Physiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Nesina Avdagić ; Department of Human Physiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Nermina Babić ; Department of Human Physiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Orhan Lepara ; Department of Human Physiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Esad Pepić ; Department of Pathophysiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Amela Dervišević orcid.org/0000-0002-4251-1437 ; Department of Human Physiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Jasminko Huskić ; Department of Human Physiology, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Abstract

Background: The aim of the present study was to evaluate serum nitric oxide (NO) and C reactive protein (CRP) concentration in veterans with and without PTSD. Furthermore, we aimed to assess whether there is a correlation between serum NO and CRP concentrations in tested groups.
Subjects and methods: Cross-sectional study included 90 male individuals, with and without experience of direct war combat, divided into three equal groups (n=30): group 1- included war veterans with PTSD, group 2 - included war veterans without PTSD, and control group - 30 apparently healthy volunteers, without experience of direct war combat. The diagnosis of PTSD was assessed according to the guidelines in the 10th revision of the International Classification of Diseases (ICD-10). High-sensitivity CRP was determined by immunonephelometry. The serum NO level was determined by classic colorimetrical Griess reaction.
Results: Serum CRP concentration in veterans with (3.54±1.19 mg/L) and without PTSD (3.24±2.04 mg/L), was significantly higher (p<0.05) compared to control group (1.26±1.06 mg/L). Serum NO concentration in veterans with (7.64±4.43 μmol/L) and without PTSD (7.12±2.60 μmol/L) was significantly lower (p<0.05) compared to control group (11.26±7.01 μmol/L). Statistically significant correlation between serum NO and CRP concentration was determined in veterans without PTSD (r=-0.473; p<0.01). No correlation was observed between serum NO and CRP concentration in veterans with PTSD (r=0.118; p=0.534) and in control group (r=-0.067; p=0.727).
Conclusion: The present study has showed significant increase of serum CRP and significant decrease of serum NO concentrations in veterans with and without PTSD. Furthermore, statistically significant negative correlation between serum NO and CRP concentration was determined only in veterans without PTSD. Obtained results indicate that the complex mechanism of the pathogenesis of PTSD requires further research.

Keywords

C-Reactive Protein; Nitric oxide; Posttraumatic Stress disorder; Veterans

Hrčak ID:

190601

URI

https://hrcak.srce.hr/190601

Publication date:

4.12.2017.

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