Short communication, Note
In vivo Effects of Maternal Immunosupression during Pregnancy on the Immune Function of Newborn Infants
Elisa Meregalli
Martina Biggioggero
Orietta Borghi
Pierluigi Meroni
Rolando Cimaz
Abstract
When used in pregnancy, immunosuppressants can cross the placental barrier and enter foetal circulation, possibly affecting the immune system of the foetus. This study evaluated the immune function in eight children born by mothers with connective tissue diseases who received immunosuppressants (cyclosporine A or dexamethasone) during pregnancy and in six babies from mothers with similar diseases, but who did not receive any treatment. Judging by the cytokine production of interleukin-2 and interferon-γ in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.
Keywords
cyclosporine A; dexamethasone; immune function; immunosuppressants; newborns; vaccination
Hrčak ID:
143
URI
Publication date:
23.5.2005.
Visits: 2.220 *