Original scientific paper

https://doi.org/10.20471/acc.2017.56.03.03

Sensitivity of Diagnostic Tests for Dry Eye in Patients with Blepharospasm

Dubravka Biuk ; Department of Ophthalmology, Osijek University Hospital Centre, School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Maja Vinković ; Department of Ophthalmology, Osijek University Hospital Centre, School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Suzana Matić ; Department of Ophthalmology, Osijek University Hospital Centre, School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Mario Bradvica ; Department of Ophthalmology, Osijek University Hospital Centre, School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Egon Biuk ; 2Department of Orthopedic Surgery, Osijek University Hospital Centre, School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Tvrtka Benašić ; Department of Ophthalmology, Osijek University Hospital Centre, School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Abstract

The aim of the study was to evaluate diagnostic tests for keratoconjunctivitis sicca (Schirmer test, tear break-up time (TBUT) test, and corneal staining with fluorescein and lissamine green dye) in patients with blepharospasm. This prospective study included 60 female patients older than 40 with blepharospasm, divided into two groups according to clinical symptoms. For fluorescein test, the surface under the ROC curve was 1.0 with standard error (SE) 0 and 95% confidence interval (95% CI) 0.940-1.0; for Schirmer test, the surface under the ROC curve was 0.817 with SE 0.0555 and 95% CI 0.696-0.905; for lissamine green test, the surface under the ROC curve was 0.813 with SE 0.056 and 95% CI 0.691-0.902; and for TBUT test, the surface under the ROC curve was 0.772 with SE 0.061 and 95% CI 0.645-0.870. According to the results of ROC curve, which determines the sensitivity and specificity of normal values, comparison of diagnostic tests for keratoconjunctivitis sicca used in this study showed that fluorescein test had the best sensitivity and specificity. Schirmer test should be avoided in patients with blepharospasm because its results are influenced by frequent blinking and are not appropriate for study interpretation. Despite the pathologic values of TBUT test (numerically), this test is still acceptable for patients with blepharospasm because its interval takes more time than the interval between two blinks.

Keywords

Staining and labeling; Blepharospasm, Fluorescein; Lissamine green dye; ROC curve; Croatia

Hrčak ID:

191339

URI

https://hrcak.srce.hr/191339

Publication date:

1.9.2017.

Article data in other languages: croatian

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