Medicinski vjesnik, Vol. 40 No. (1-4), 2008.
Review article
Depression in patients with psoriasis
Pavo Filaković
Darko Biljan
Anamarija Petek
Abstract
Depression is a frequent psychiatric disorder in patients suffering from psoriasis. The depression and psoriasis comorbidity amounts up to 30 % and is higher than among patients in outpatient clinics of general practice, where it amounts to 22%. Authors have set a goal to prove a connection between characteristics of patients suffering from the depression and psoriasis, based on the latest literature, accessible through electronic data bases. Research results showed that patients suffering from depression and patients suffering from psoriasis have altered indicators of immunological response and higher indicators of systemic inflammation. Authors conclude that the presence ot inflammatory changes in these disorders shows that inflammatory processes are pivotal for the development of at least a part of depressive disorders and psoriasis. This is why pharmacotherapeutic approach in a combine treatment of psoriasis with a joint depression should be based on modem ideas about inclusion of hypothalamic-hypophyseal-adrenal axis, proinflammatory mediators of immunological response (IL-1, IL-6, TNF-") and acute inflammation phase proteins (C-reactive protein) into pathogenesis of both disorders. The key for successful treatment lies in team approach to such patient under the scope of liaison psychiatry, which provides a frame for successful cooperation between a dermatologist and a psychiatrist.
Keywords
Depression; Psoriasis; Psychodermatology
Hrčak ID:
191469
URI
Publication date:
1.12.2008.
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