Medicinski vjesnik, Vol. 40 No. (1-4), 2008.
Review article
Anesthetic-induced cardiac preconditioning
Danijel Pravdić
Filip Sedlić
Ana Šepac
Željko Bošnjak
Abstract
Anesthetic preconditioning (APC) describes the protection of myocardium in ischemia and reperfusion injury obtained from applying volatile anesthetics before an ischemic event. Various intracellular kinases, mitochondrial and sarcolemmal ATP-sensitive K+ channels, and reactive oxygen species play a pivotal role in the signal transduction cascade in APC. The other cellular components involved in APC include but are not limited to: glycogen synthase kinase 3-beta, vascular endothelial growth factor, hypoxia inducible factor 1 alpha, nitric oxide synthase, and different intracellular kinases (e.g. protein tyrosine and protein serine-threonine kinases). Mitochondria are an integral part in the mechanism of cell death as well as cellular protection by preconditioning. Moreover, it has been suggested that APC reduces cardiomyocyte death through the inhibition of mitochondrial permeability transition pore opening. This review article addresses current concepts and controversies regarding the specific roles of the mitochondria in cardioprotective signaling by volatile anesthetics.
Keywords
Anesthetic preconditioning; Ischemia-reperfusion injury; Mitochondria: Reactive oxygen species; Inhalational anesthetics
Hrčak ID:
191484
URI
Publication date:
1.12.2008.
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