Medicinski vjesnik, Vol. 42 No. (1-2), 2010.
Original scientific paper
Antibiotic prophylaxis in patients undergoing colorectal cancer resection
Marijan Kolovrat
Dražen Servis
Željko Bušić
Abstract
Surgical site infection remains one of the most frequent postoperative complications, leading to prolonged hospital stay and morbidity as well as increased treatment costs. Efforts to decrease incidence of surgical site infections are various, including improving preoperative skin preparation, surgical technique, antibiotic prophylaxis and postoperative patient management. Optimal antibiotic prophylaxis in colorectal surgery is yet to be determined, although there are various recommended regimes. Patients operated for colorectal cancer at our department were retrospectively analyzed. The patients were grouped according to the antibiotic prophylaxis they received. Earlier group of patients received gentamicin and metronidazole and later group received cefazolin and metronidazole. In both groups antibiotic prophylaxis was initiated immediately before surgery and maintained for 24 hours. 57 patients who received gentamicin and metronidazole and 35 patients who received cefazolin and metronidazole were analyzed. Incidence of surgical site infection in the latter group was 6%, compared with 24% (p<0,05) in the group of patients who received gentamicin and metronidazole. This study indicates that a combination of cefazolin and metronidazole administered for 24 hours is effective as antibiotic prophylaxis in patients undergoing colorectal surgery.
Keywords
Colorectalneoplasms - surgery; Antibiotic prophylaxis
Hrčak ID:
191872
URI
Publication date:
1.12.2010.
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