Medicinski vjesnik, Vol. 42 No. (3-4), 2010.
Original scientific paper
Nanocomplexes of polymers and surfactant in drug delivery
Marko Vinceković
Marija Bujan
Abstract
Nanocomplexes formed from anionic biopolymers, carrageenans, and cationic surfactant have been investigated for their applicability in drug delivery. Stucture and complex size from nano- to microdimension strongly depends on concentration and concentration ratio of both components and linear charge density on carrageenan chains. Factors governing the complex formation are electrostatic and hydrophobic interactions as well as conformation of the carrageenan chains. With increasing carrageenan concentration, the intra-macromolecular complexes change to inter-macromolecular, which subsequently reorganize into bettei ordered structures, giant vesicles, precipitate - dodecylammonium carrageenate and gels. Formation of giant vesicles and structural properties of insoluble complexes and collapsed gels revealed lamellar ordering as an important feature of the carrageenan and an oppositely charged surfactant complexes.
Keywords
Surface-active agents; Complexes; Drug delivery systems; Vesicles
Hrčak ID:
191921
URI
Publication date:
1.12.2010.
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