Review article

Bacterial Sexually Transmitted Diseaes as a Risk Factor for Cervical Cancer: Contemporary Therapeutic Approaches

Višnja Škerk
Tamara Žigman

Abstract

Persistent infections with human papillomavirus
have proven to be a risk factor for cervical lesions and
cancer. However, C. trachomatis infection is also suspected to
play a role in the development of preinvasive cervical lesions
and cancer. C. trachomatis infection is often associated with the
HPV infection. C. trachomatis modifi es the HPV action on epithelial
cervical cells. The latest research points out to molecular
mechanisms of oncogenesis in C. trachomatis infection.
Gonorrhea and other sexually transmitted diseases are risk
factors for the development of cervical carcinoma, and they are
a marker of HPV and risky sexual behavior of a diseased person.
Microorganims in bacterial vaginosis may affect the cervical
epithelium through the local production of nitrosamine in the
vagina. They are more often present in women with cervical
dysplasia.

Keywords

cervical cancer; sexually transmitted infections; risk factors

Hrčak ID:

18160

URI

https://hrcak.srce.hr/18160

Publication date:

29.12.2006.

Article data in other languages: croatian

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