Medicinski vjesnik, Vol. 31 No. (1-4), 1999.
Professional paper
Experimental models in the research of the early embriogenesis
Ljiljana Kostović-Knežević
Srećko Gajović
Tatjana Belovari
Abstract
The period of continuous and internationally recognized research in developmental biology began in Croatia in the early fifties. It was initiated by Nikola Škreb and continued by his coworkers. His research was focused to the analysis of the early postimplantation rodent embryo with special attention on the crucial period of gastrulation. The next step was the analysis of growth and histological differentiation after transfer of embryos and separated germ lyers to ectopic sites (kidney capsule, anterior chamber of the eye, chorioalantois membrane). The potential of early rat embryo to grow and differentiate was shown using a method of organ culture in vitro. After establishing molecular methods and identification of genes involved in the development, the same developmental problems are investigated in a new way. One of them is the gene trap procedure, which utilises the possibility to select trapped genes active during embryogenesis.
Keywords
Experimental models; Mammalian embriogenesis; Research
Hrčak ID:
191960
URI
Publication date:
1.12.1999.
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