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Biochemia Medica, Vol. 28 No. 1, 2018.

Other

https://doi.org/10.11613/BM.2018.010801

Henoch-Schönlein purpura in the third trimester of pregnancy

Ivka Djakovic orcid id orcid.org/0000-0003-2275-6389 ; Department of Gynaecology and Obstetrics, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Drazan Butorac orcid id orcid.org/0000-0002-1863-8198 ; Department of Gynaecology and Obstetrics, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zeljko Vucicevic ; Department of Internal Medicine, Intensive Care Unit, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Vesna Kosec orcid id orcid.org/0000-0002-2863-0034 ; Department of Gynaecology and Obstetrics, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Andrea Tesija Kuna orcid id orcid.org/0000-0001-6871-2686 ; University Department of Chemistry, Medical School Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Liborija Lugović-Mihić ; Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

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Abstract

Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessels’ vasculitis that affects the skin, intestines and kidneys. Pregnancy has been reported
as an exacerbating factor. We present the case of a 24-year-old primigravida with HSP that occurred in the third trimester and lasted up to the
end of the successful delivery. She had pruritic maculopapular exanthema on her legs. Biopsy of a cutaneous lesion was performed for histopathologic
features and direct immunofluorescence (DIF) for the presence of perivascular IgA deposition. Histopathology of the cutaneous lesion confirmed
leukocytoclastic vasculitis. A DIF examination of the skin lesion confirmed deposits of fibrinogen in the small blood vessel walls. Six weeks following
delivery, the skin lesions almost completely disappeared. Control laboratory findings were normal. This case of HSP might have been primarily associated
with a preceding respiratory infection but this should first be carefully investigated due to a possible severe immunological disease in the
patient’s background requiring special attention since nephrotic symptoms may occur.

Keywords

Henoch-Schönlein purpura; leukocytoclastic vasculitis; pregnancy; glomerulonephritis; preeclampsia

Hrčak ID:

192390

URI

https://hrcak.srce.hr/192390

Publication date:

15.2.2018.

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