Medicinski vjesnik, Vol. 27 No. (1-2), 1995.
Other
Second messengers in the nucleus
Hrvoje Banfić
Mirza Žižak
Abstract
The ability of cells to respond to external stimuli involves the transduction of messages across the plasma membrane and their translation into internal signal, second messengers, which control many cell processes such as cell growth, differentiation and proliferation. A prominent role in message transduction is played by phosphoinositides, minor membrane lipids, whose breakdown through phospholipase C produces the second messengers: inositol-(l,4,5)- trisphosphate, inositol-( 1,3,4,5)-tetraphosphate and sn-l,2-diacylglycerol. Inositol (l,4,5)-trisphosphate and Ins(l,3,4,5)P-tetrakisphosphate, released into the cytoplasm, mobilize calcium from internal stores, whereas sn-l,2 diacylglycerol activates protein kinase C. Recent studies suggested the existence of a discrete signal system in the nuclei. It includes all components of well-known plasma membrane-located system, which is under regulatory control by cell surface-located receptors. It remains to be clarified whether the nuclei signal system is a part of the general signal system originating at plasma membrane, or whether it is independent of it.
Keywords
Hrčak ID:
192578
URI
Publication date:
1.12.1995.
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