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Diabetic Nephropathy with Focal Segmental Glomerulosclerosis

Krešimir Galešić
Danica Ljubanović
Josip Pavan
Ivana Račić

Abstract

The association of diabetic nephropathy with primary glomerulonephritis in type 1 diabetes is rare. Several reports have shown that primary glomerulonephritis can be superimposed on diabetic nephropathy. These glomerulonephritides include idiopathic membranous glomerulonephritis, IgA glomerulonephritis, Henoch-Schönlein nephritis, membranoproliferative glomerulonephritis, lupus nephritis, minimal change disease, postinfectious glomerulonephritis and rapidly progressive glomerulonephritis. Because some of these disorders can alter the management and prognosis of renal disease in diabetic patients, the appearance of urinary abnormalities or deterioration in renal function inconsistent with the natural history of diabetic nephropathy raises the possibility of a nondiabetic renal disease and should lead to a more detailed evaluation. We report on a patient with type 1 diabetes that underwent renal biopsy because of heavy proteinuria and nephrotic syndrome. Renal biopsy showed diabetic nephropathy coexistent with focal segmental glomerulosclerosis. To the best of our knowledge, this is the first reported case of primary focal segmental glomerulosclerosis associated with diabetic nephropathy and diabetic retinopathy, with excellent therapeutic response.

Keywords

Glomerulosclerosis, focal - complications; Glomerulosclerosis, focal - diagnosis; Glomerulosclerosis, focal - therapy; Diabetic nephropathies - diagnosis; Diabetic nephropathies - immunology; Diabetic nephropathies - therapy; Kidney, glomerules - patholog

Hrčak ID:

18265

URI

https://hrcak.srce.hr/18265

Publication date:

3.9.2007.

Article data in other languages: croatian

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