Short communication, Note

https://doi.org/10.2478/acph-2018-0014

Topical antifungal bigels: formulation, characterization and evaluation

AGNE MAZURKEVICIUTE ; Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania
KRISTINA RAMANAUSKIENE ; Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania
MARIJA IVASKIENE ; Department of Non-infectious Diseases, Faculty of Veterinary Medicine, Veterinary Academy, Lithuanian University of Health Science, 47181 Kaunas, Lithuania
AIDAS GRIGONIS ; Department of Non-infectious Diseases, Faculty of Veterinary Medicine, Veterinary Academy, Lithuanian University of Health Science, 47181 Kaunas, Lithuania
VITALIS BRIEDIS ; Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania

Abstract

Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel. All formulations showed great inhibition of Microsporum canis. Thus, bigels with ciclopirox olamine and terbinafine hydrochloride are a promising dosage form for topical use.

Keywords

bigel; ciclopirox olamine; terbinafine hydrochloride; poloxamer 407; antifungal; Microsporum canis

Hrčak ID:

193564

URI

https://hrcak.srce.hr/193564

Publication date:

30.6.2018.

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