Original scientific paper

https://doi.org/10.2478/acph-2018-0015

Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats

NUNTIYA SOMPARN orcid.org/0000-0002-9134-0099 ; Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, PathumThani, Thailand 12120
SUPHAKET SAENTHAWEEUK ; Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, PathumThani, Thailand 12120
JARINYAPORN NAOWABOOT ; Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, PathumThani, Thailand 12120
ATCHARAPORN THAEOMOR ; School of Biology, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand 3000
VEERAPOL KUKONGVIRIYAPAN ; Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand 40002

Abstract

Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found in the extract. The extract significantly decreased total cholesterol, low-density lipoprotein and atherogenic index in rats after treatment (p < 0.05). Expression of genes and protein of sterol regulatory element binding protein-1c (SREBP1c) and HMG-CoA reductase (HMGR) was also lowered significantly in treated groups (p < 0.05). Moreover, serum antioxidant capacity increased in treated rats in comparison with untreated ones (p < 0.05) and was associated with decreased serum lipid peroxidation.

Keywords

Cymbopogon citratus; lipid profile; antioxidant; SREBP1c; HMG-CoA reductase

Hrčak ID:

193568

URI

https://hrcak.srce.hr/193568

Publication date:

30.6.2018.

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