Medicinski vjesnik, Vol. 25 No. (1-2), 1993.
Original scientific paper
The specific immunological reactivity in breast cancer patients
Damir Eljuga
Josip Fajdić
Ljerka Eljuga
Marica Vrdoljak
Abstract
We used the leukocyte adherence inhibition (LAI) assay in detecting the specific immune reactivity and monitoring of the dynamics of this immunity in 58 breast cancer patients. We wanted to find out if the level of preoperative specific immune reactivity is in correlation with the survival rate. Soluble antigenic preparations from a breast cancer, rectal carcinoma and fibroadenoma were obtained with 3M KCI. 72% of breast cancer patients showed the specific reactivity to the allogeneic KCI extract from reast carcinoma. Stage II and III patients react better than stage I patients (82% versus 50%). The specific reactivity after surgery and postoperative radiotherapy decreased in stage II and III patients. The reactivity in stage I patients was at the same level during six months. The LAI reacitivity prior to surgery correlates with significantly higher 6-years survival rate.
Keywords
immunological reactivity; LAI assay; breast cancer
Hrčak ID:
194004
URI
Publication date:
1.12.1993.
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