Original scientific paper

Structure - Activity Relationships in the Antiinflammatory Steroids: A Pattern Recognition Approach

Nicholas Bodor ; College of Pharmacy Department of Medicinal Chemistry Box J-4, J. H. Miller Health Center University of Florida Gainesville, Florida 32610
Alan J. Harget ; College of Pharmacy Department of Medicinal Chemistry Box J-4, J. H. Miller Health Center University of Florida Gainesville, Florida 32610
Edward Phillips ; College of Pharmacy Department of Medicinal Chemistry Box J-4, J. H. Miller Health Center University of Florida Gainesville, Florida 32610

Abstract

A pattern recognition technique has been used to determine
structure-activity relationships for antiinflammatory steroids. Expe.:.
rimental results using the human vasoconstrictor test of McKenzie
and Stoughton and the rat granuloma cotton pellet method of
Meier were correlated with the various substructural descriptors.
Steroids were classified into two categories according to potency
and a pattern recognition method was applied to determine their
relative ranking. The resulting structure-activity relationships
obtained and the relative contributions of the various structural
variables for both bioassays are discussed. A synergistic effect
was predicted to be in operation between certain pairs of substituents.

Keywords

Hrčak ID:

194222

URI

https://hrcak.srce.hr/194222

Publication date:

30.6.1983.

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