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Original scientific paper

Synthesis of New Formyl Halo N-methylimidazole Derivatives

M. El Borai ; Department of Chemistry, Faculty of Science, University of Tanta and University of Ain Shams, Egypt
A. H. Moustafa ; Department of Chemistry, Faculty of Science, University of Tanta and University of Ain Shams, Egypt
M. Anwar ; Department of Chemistry, Faculty of Science, University of Tanta and University of Ain Shams, Egypt
A. G. Ghattas ; Department of Chemistry, Faculty of Science, University of Tanta and University of Ain Shams, Egypt


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Abstract

Bromo-formyl imidazoles 16-20 have been prepared by three
different ways. The first consisted of conversion of bromo or iodo
imidazoles 1-6 into diethyl acetals 13-15, and subsequent hydrolysis
into formyl derivatives 7-9. In the second, bromination of.
formyl imidazoles with NBS afforded compounds 16-18 in 45-70°/o
yield. The third method used direct formylation of bromo imidazoles
10-12 with n-BuLi/DMF reagent into compounds 16, 19, and 20.

Keywords

Hrčak ID:

194338

URI

https://hrcak.srce.hr/194338

Publication date:

20.7.1981.

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