Original scientific paper
Comparative analysis of testicular tumors in men and dogs in the Republic of Croatia
Marko Hohšteter
orcid.org/0000-0001-8844-2660
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Branka Artuković
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marijana Ćorić
; University Hospital Centre Zagreb, Department of Pathology and Cytology , Zagreb, Croatia
Krešimir Severin
; Department of Forensic and State Veterinary Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Andrea Gudan Kurilj
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ana Beck
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ivan-Conrado Šoštarić-Zuckermann
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Željko Grabarević
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Abstract
Testicular tumors are among most prevalent tumors in men and dogs. Germ cell tumors have different biological behavior, but are morphologicaly similar and very frequent in both species. Material and methods:Testicles from necropsied dogs and the samples of biopsed canine tumors, from the Faculty of Veterinary Medicine, Zagreb, are analyzed. Analyzed are also samples of biopsed men tumors from the Pathology Depertment, University Hospital Centre Zagreb. Results:Testicular tumors were found in 52% of necropsied, and regarding other biopsed tumors testicular comprised 7% of all biopsed canine tumors. Median age of necropsied dogs with testicular tumors was 10,16 and for biopsed dogs 10,24 years. Human patients developed
testicular tumors at a medium age of 33,35 years. In the necropsied dogs group most frequent were Leydig cell tumors, and in biopsed group most common were seminomas. Additionaly in both groups very frequent were also Sertoli cell tumors, mixed tumors and GCNIS. GCNIS
are additionaly found in 25% of necropsied and 19% of biopsed dog testicles. In the human testicles, most frequently diagnosed were seminomas, embrional carcinomas, teratomas, GCNIS and mixed germ cell tumors. GCNIS as additional alterations were diagnosed in 65%
of human testicular tumors. Performed immunohistochemical analysis showed that investigated markers are useful for differentiation of canine testicular tumors. In dogs, cytokeratin AE1/AE3 showed particularly good results in differentiation of stromal tumor, especially Sertoli cell tumors from the germ cell tumors. c-KIT and PLAP showed higher expression in germ cell tumors, and PLAP showed expression in GCNIS of the dogs. CD 30 was weakly expressed in canine tumors. Discussion and conclusions:Conducted histopatological analyis and application of PLAP proving existance of GCNIS in canine testicles. Expression of c-KIT confirmed that canine seminomas can be, like in human, classified into two groups: c-KIT positive classical seminomas and c-KIT negativne spermatocytic tumors.
Keywords
dog; human; tumor; testis; pathology; immunohistochemistry
Hrčak ID:
195082
URI
Publication date:
6.3.2018.
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