Medicinski vjesnik, Vol. 24 No. (3-4), 1992.
Original scientific paper
The changes of basal blood gastrin level in patients with duodenal ulcer during treatment with famotidine and omeprazole
Aleksandar Včev
Ivan Čandrlić
Branko Dmitrović
Milivoj Rubinić
Davor Štimac
Abstract
Omeprazole (20 mg o.m.) was compared to famotidine (40 mg h.s.) in treatment of duodenal ulcer in a single-blind randomized comparative trial along with concentrations of basal gastrin in serum during treatment and one week after ulcer healing. Patients were divided into two groups (each 40 patients). There were no significant differences between the groups in baseline characteristics (including age, sex, manfemale ratio, smoking, alcohol consumption and ulcer size). Rapidity of ulcer healing was documented by endoscopy. Duodenal ulcer heald up after two weeks in 85% of patients treated with omeprazole and in 60% treated with famotidine, and after 28 days in 97,5% of patients treated with omeprazole and in 82,5% treated with famotidine.
Keywords
gastrin; duodenal ulcer; famotidine; omeprazole
Hrčak ID:
195510
URI
Publication date:
1.12.1992.
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