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Review article

ß-lactamases of Moraxellae catarrhalis and susceptibility to antibiotics

Branka Bedenić
Živojin Žagar


Full text: croatian pdf 2.523 Kb

page 295-300

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Full text: english pdf 2.523 Kb

page 295-300

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Abstract

M. catarrhalis is gaining increasing interest as respiratory tract pathogen. High percent of clinical isolats rpoduces ß- lactamase which is responsible for resistance to bea-lactam antibiotics, especially to ampicillin and penicillin. M. catarrhalis produces two main types of ß lastamase: BRO-1 and BRO-2. The both are plasmid mediated, hydrolize penicillin at much higher rate the cephalosporins and are biosinthetised constitutively. They are very sensitive to inhibition by clavulanic acid. The B-lactamase producing strains are in, general resistant, to penicillins. The combination of amoxycillin and clavuranic acid represents the first choice antibiotic in the therapy of infections caused by M. catarrhalis. Eritromycin and cephalosporins can be used too.

Keywords

Moraxella catarrhalis; ß-lactamase; penicillins; clavulanic acid

Hrčak ID:

195517

URI

https://hrcak.srce.hr/195517

Publication date:

1.12.1992.

Article data in other languages: croatian

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