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Croatica Chemica Acta, Vol. 52 No. 3, 1979.

Original scientific paper

Aliphatic Thymidine and Deoxyuridine Analogs

V. Škarić ; Laboratory of Stereochemistry and Natural Products, »Ruder Boskovic« Institute, 41001 Zagreb, Croatia, Yugoslavia
D. Erben ; Laboratory of Stereochemistry and Natural Products, »Ruder Boskovic« Institute, 41001 Zagreb, Croatia, Yugoslavia
Z. Raza ; Laboratory of Stereochemistry and Natural Products, »Ruder Boskovic« Institute, 41001 Zagreb, Croatia, Yugoslavia
Đ. Škarić ; Laboratory of Stereochemistry and Natural Products, »Ruder Boskovic« Institute, 41001 Zagreb, Croatia, Yugoslavia

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Abstract

The oxidation of 1-allyluracil (I) and 1-allylthymine (II) by the
silver acetate-iodine method into the corresponding 1-(2,3-dihydroxypropyl)
derivatives (III) and (IV) was described: The selective
tritylation of the glycol (IV) into 1-(3-0-triphenylmethyl-2,3-dihydroxypropyl)
thymine (X) made feasible the synthesis of 1-(2,3-
-dihydroxypropyl)thymine-2'-phosphate as barium salt (XVII) and
thymidylyl (5'-+2')-1-(2,3-dihydroxypropyl)-thymine as ammonium
salt (XXII).

Keywords

Hrčak ID:

195888

URI

https://hrcak.srce.hr/195888

Publication date:

20.11.1979.

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