Conference paper

Surface Activity and Mechanism of Action of Antiarrhythmic Drugs

V. V. Zakusov ; Institute of Pharmacology, Academy of Medical Sciences Moscow, USSR, Institute of Cardiology, Yerevan, Armenia
N. T. Pryanishnikova ; Institute of Pharmacology, Academy of Medical Sciences Moscow, USSR, Institute of Cardiology, Yerevan, Armenia
V. M. Samvelyan ; Institute of Pharmacology, Academy of Medical Sciences Moscow, USSR, Institute of Cardiology, Yerevan, Armenia

Abstract

Surface active substances are widely used in medicine, among
them the drugs capable of adsorption in efficient concentrations at
various interface points. The relationship between the pharmacological
action of a ntiarrhythmic drugs and their surface activity and
influence on the lipid-containing interfaces (bimolecular layers of
phosphatidylcholine) have been studied. It has been revealed that
diphisopronyle (diethylaminopropyl ether a-isopropyloxydiphenylacetic
acid, hydrochloride), fubromegane (1-methyl-3-diethylaminopropyl
ether 5-bromofurane-2-carboxylic acid, iodomethylate), methamicile
(~-diethylaminopropyl ether benzyl acid, hydrochloride),
propranolole (l-isopropylamino-3 (oxynaphtyl-1)--propanol-2, hydrochloride),
chinidine (chinidine sulphate), novocainamide (~-diethylaminoethyl-
amid p-aminobenzoic acid, hydrochloride), novocaine
(~ -diethylaminoethyl ether p-aminobenzoic acid, hydrochloride), xylocaine
(N,N-diethylamino-2,6-dimethylacethanilide, hydrochloride),
trimecaine (N,N-diethylamino-2,4,6-trimethylacethanilide, hydrochloride)
possess surface activity. Parallelism between the physiological
action and interfacial activity of antiarrhythmic drugs has
been established. Antiarrhythmics increase the electric conductance
of lecithine bilayers. There exists a symbate dependence between
the effect of drugs on the permeability of a bimolecular lecithin
membrane and . their pharmacological activity. These results are
essential a) for understanding the mode of action of antiarrhythmic
agents and b) discovering new drugs which possess the required
properties.

Keywords

Hrčak ID:

195905

URI

https://hrcak.srce.hr/195905

Publication date:

25.6.1979.

Visits: 690 *